| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763024 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠We investigated the effect of TSA, one of most potent HDACIs, on myogenesis using the C2C12 skeletal muscle cell line. ⺠TSA enhances the expression of myosin heavy chain without affecting DAPC expression. ⺠TSA enhances the expression of the early MRFs, Myf5 and MEF2, and suppresses the late MRF, myogenin, after 24 h treatment. ⺠TSA enhances the expression of the myogenic repressors, Ids, which inhibit myogenic differentiation. ⺠TSA promotes myogenesis by coordinating the expression of MRFs and myogenic repressors.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Hiroki Hagiwara, Fumiaki Saito, Toshihiro Masaki, Miki Ikeda, Ayami Nakamura-Ohkuma, Teruo Shimizu, Kiichiro Matsumura,