| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763030 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠This is the first study to characterize Claspin gene knockout cells using DT40 cells. ⺠Claspin plays a critical role in DNA replication in the absence of exogenous stress. ⺠This is the first study to reveal the functional relationship between Claspin and Rad17. ⺠RAD17â cells observed a greater defect in MMS-induced checkpoint activation than Claspinâ/â cells. ⺠Knocking out RAD17 gene showed almost no additive effects in Claspinâ/â cells.
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Authors
Akari Yoshimura, Motomu Akita, Yoshifumi Hosono, Takuya Abe, Masahiko Kobayashi, Ken-ichi Yamamoto, Shusuke Tada, Masayuki Seki, Takemi Enomoto,