Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1

Article ID	Journal	Published Year	Pages	File Type
10763035	Biochemical and Biophysical Research Communications	2011	5 Pages	PDF

Abstract

âº We investigate physiological roles of the BMP receptor ACVR1, a potent receptor for BMP7. âº Loss of ACVR1 in osteoblasts increases bone mass and activates Wnt signaling in mice. âº Wnt inhibitors SOST and DKK1 are both downregulated in the mutant bones. âº ACVR1 can repress osteogenesis and Wnt signaling via SOST/DKK1. âº This study proposes a new concept of the BMP7-ACVR1-SOST/DKK1 axis in osteoblasts.

Keywords

Wnt TGF-β Sost ACVR1 fibrodysplasia ossificans progressiva DKK1 DEXA BMPR HBM FOP qRT-PCR ALK Osteoblast transforming growth factor-β High bone mass embryonic day postnatal day BMP quantitative reverse transcription polymerase chain reaction Bone morphogenetic protein activin receptor-like kinase BMP receptor