Article ID Journal Published Year Pages File Type
10763037 Biochemical and Biophysical Research Communications 2011 7 Pages PDF
Abstract
► We study the region of caveolin-1 that interacts with ABCA1 and effect on cellular HDL-mediated cholesterol efflux. ► Deleted oligomerization domain of caveolin-1, caveolin-1Δ62-100, is required for the interaction of caveolin-1 with ABCA1. ► Caveolin-1Δ62-100 did not colocalize with ABCA1 in the cholesterol-loaded cells after HDL incubation. ► Caveolin-1Δ62-100 suppressed HDL-mediated cholesterol efflux.
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