Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10763052 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠We decipher intracellular signaling pathways that induce the phosphorylation/inactivation of PTEN. ⺠Elevated reactive oxygen species (ROS) in AMD model mouse RPE trigger PTEN phosphorylation. ⺠The ROS-induced PTEN phosphorylation was not mediated by either GSK3 or CKII, two known PTEN kinases. ⺠The Akt-independent PI3K signaling pathway is responsible for PTEN phosphorylation in oxidatively damaged RPE.
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Authors
Eun Jung Lee, Namsuk Kim, Kyung Hwa Kang, Jin Woo Kim,