| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763052 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠We decipher intracellular signaling pathways that induce the phosphorylation/inactivation of PTEN. ⺠Elevated reactive oxygen species (ROS) in AMD model mouse RPE trigger PTEN phosphorylation. ⺠The ROS-induced PTEN phosphorylation was not mediated by either GSK3 or CKII, two known PTEN kinases. ⺠The Akt-independent PI3K signaling pathway is responsible for PTEN phosphorylation in oxidatively damaged RPE.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Eun Jung Lee, Namsuk Kim, Kyung Hwa Kang, Jin Woo Kim,