| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763106 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠The development of atherosclerosis and abdominal aortic aneurysms involves the degradation of extracellular matrix components, such as collagen and elastin. ⺠Releases of the elastin cross-links desmosine (DES) and isodesmosine (IDE) may reflect elastin degradation in cardiovascular diseases. ⺠Exposure of insoluble elastin to monocyte/macrophage-conditioned media or recombinant MMP-12 and neutrophil elastase liberated DES and IDE as amino acids. ⺠Elastin oxidized by reactive oxygen species (ROS) liberated more DES and IDE than did non-oxidized elastin. ⺠The results of this study support the exploration of free DES and IDE as biomarkers of elastin degradation.
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Authors
Hideyuki Umeda, Masanori Aikawa, Peter Libby,