Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10763124 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Both Ca++-Calmodulin (CaM) and Ca++-free CaM bind to the C-terminal region of Nav1.1. ⺠Ca++ and CaM have both opposite and convergent effects on INav1.1. ⺠Ca++-CaM modulates INav1.1 amplitude. ⺠CaM hyperpolarizes the voltage-dependence of activation, and increases the inactivation rate. ⺠Ca++ alone antagonizes CaM for both effects, and depolarizes the voltage-dependence of inactivation.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Christelle Gaudioso, Edmond Carlier, Fahamoe Youssouf, Jeffrey J. Clare, Dominique Debanne, Gisèle Alcaraz,