Article ID Journal Published Year Pages File Type
10763124 Biochemical and Biophysical Research Communications 2011 6 Pages PDF
Abstract
► Both Ca++-Calmodulin (CaM) and Ca++-free CaM bind to the C-terminal region of Nav1.1. ► Ca++ and CaM have both opposite and convergent effects on INav1.1. ► Ca++-CaM modulates INav1.1 amplitude. ► CaM hyperpolarizes the voltage-dependence of activation, and increases the inactivation rate. ► Ca++ alone antagonizes CaM for both effects, and depolarizes the voltage-dependence of inactivation.
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