Article ID Journal Published Year Pages File Type
10763129 Biochemical and Biophysical Research Communications 2011 6 Pages PDF
Abstract
► The expression of phage-displayed disulfide-stabilized sc-dsFv libraries can be drastically enabled with novel signal sequences. ► The effective signal sequence variants in the h-region are not necessarily composed of consecutive hydrophobic residues. ► Synthetic sc-dsFv library complexities are comparable with the scFv-based libraries. ► The disulfide-stabilized sc-dsFv format is a viable alternative for scFv-based applications.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Effects of signal sequence on phage-displayed disulfide-stabilized single chain antibody variable fragment (sc-dsFv) libraries
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