Article ID Journal Published Year Pages File Type
10763146 Biochemical and Biophysical Research Communications 2011 6 Pages PDF
Abstract
► Mechanisms for preadipocyte hyperplasia by pioglitazone, a PPARγ agonist, are shown. ► Pioglitazone promotes cell-cycle of 3T3-L1 preadipocytes and increases their number. ► Pioglitazone downregulates a cyclin dependent kinase inhibitor, p16Ink4a. ► PPARγ transrepresses p16Ink4a gene in preadipocytes, which pioglitazone enhances.
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