Isoflurane preconditioning involves upregulation of molecular chaperone genes

Article ID	Journal	Published Year	Pages	File Type
10763158	Biochemical and Biophysical Research Communications	2011	6 Pages	PDF

Abstract

âº Isoflurane binding and dissociation causes a persistent protein conformational change. âº Anesthetic preconditioning shows an early and delayed phase. âº Isoflurane exposure upregulates 45 heat shock genes through both phases. âº Seventeen heat shock genes are specifically upregulated during the early phase. âº Nine heat shock genes exhibit a delayed upregulation after isoflurane exposure.

Keywords

FBS HSA center of spectral mass qRT-PCR RFU UPR CSM AUC gene array human serum albumin Isoflurane fetal bovine serum Protein misfolding area under the curve Relative Fluorescence Units quantitative real time polymerase chain reaction Unfolded protein response Heat shock proteins Preconditioning