| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763161 | Biochemical and Biophysical Research Communications | 2011 | 4 Pages |
Abstract
⺠We did systemic comparison of repression activity for miRNA and siRNA associated with different types of target sequences. ⺠The level of repression could be ordered as follows: perfect-matched target â«Â dimeric targets â«Â monomeric targets. ⺠Fold repression of 8mer + 7mer-1A lay between 2 Ã 8mer and 2 Ã 7mer-1A. ⺠A mismatch in one seed dramatically decreasing repressive activity of the dimer indicating cooperation of two monomers. ⺠Strong repression of miR-155 and siRNA-155 (siRNA carrying miR-155 sequence) with perfectly matched target was due primarily to translational attenuation.
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Authors
Han-Chia Lee, Chih-Ying Chen, Lo-Chun Au,