Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10763260 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠The hypnotic effect of ILTG was fully inhibited by flumazenil, a benzodiazepine antagonist. ⺠ILTG was, for the first time, characterized as a GABAA-benzodiazepine receptor ligand. ⺠ILTG (10â5 M) potentiated GABA-evoked currents to 151% of the control level on dorsal raphe neurons. ⺠The ILTG effect on GABA currents was blocked by 10â7 M flumazenil. ⺠ILTG exerts a hypnotic effect by positive allosteric modulation of GABAA receptors.
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Authors
Suengmok Cho, Sojin Kim, Zhenhua Jin, Hyejin Yang, Daeseok Han, Nam-In Baek, Jinho Jo, Chang-Won Cho, Ji-Hae Park, Makoto Shimizu, Young-Ho Jin,