| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763273 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠A novel carboxyl-terminally truncated scorpion alpha-toxin (MeuNaTxα(NT)-1) was chemically synthesized. ⺠MeuNaTxα(NT)-1 has unique structure different from other scorpion alpha-toxins. ⺠The truncated peptide acts as a blocker of sodium channels rather than a gating modulator. ⺠This work provides a clue for evolution-guided design of channel blockers for therapeutic aims.
Keywords
reversed-phase high-pressure liquid chromatographyDRGMesobuthus eupeusVGSCORFNMDIC50TTXPSCRP-HPLCnuclear magnetic resonance3′-UTR50% inhibitory concentrationInhibitortetrodotoxinNMRcircular dichroismRetention timeMatrix-assisted laser desorption ionization time-of-flight mass spectrometrynonsense-mediated mRNA decayopen reading frameMALDI-TOF MSModulatorvoltage-gated sodium channelVoltage-gated potassium channelIon channelpremature stop codondorsal root gangliaDorsal root ganglion (DRG)
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Authors
Bin Gao, Limei Zhu, Shunyi Zhu,