Article ID Journal Published Year Pages File Type
10763305 Biochemical and Biophysical Research Communications 2011 6 Pages PDF
Abstract
► We examine the role of Oct4 in metastasis in cultured MCF-7 cells. ► The down regulation of Oct4 induces EMT and increases the capability of migration and invasion in MCF-7 cells. ► TGF-β1 inhibits Oct4 expression in both time- and dose-dependent manners. ► The EMT induced by TGF-β1 or down regulation of Oct4 could be abrogated by inhibitor of SOCE. ► The down regulation of STIM1 (one of the major components of the CRAC channel) alleviates the EMT induce by Oct4 silencing down.
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