Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10763305 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠We examine the role of Oct4 in metastasis in cultured MCF-7 cells. ⺠The down regulation of Oct4 induces EMT and increases the capability of migration and invasion in MCF-7 cells. ⺠TGF-β1 inhibits Oct4 expression in both time- and dose-dependent manners. ⺠The EMT induced by TGF-β1 or down regulation of Oct4 could be abrogated by inhibitor of SOCE. ⺠The down regulation of STIM1 (one of the major components of the CRAC channel) alleviates the EMT induce by Oct4 silencing down.
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Authors
Jiajia Hu, Kunhua Qin, Yan Zhang, Junbo Gong, Na Li, Dan Lv, Rong Xiang, Xiaoyue Tan,