| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763316 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠We demonstrated a potent inhibitory effect of curcumin on TGF-β signaling in scleroderma fibroblasts. ⺠Curcumin counteracted TGF-β-induced phosphorylation of Smad2 but not Smad3. ⺠Curcumin induced upregulation of TGF-β-induced factor (TGIF), which is required in curcumin-mediated TGF-β/Smad2 suppression. ⺠The upregulation of TGIF by curcumin might result from decreased ubiquitination of TGIF, which blocks its proteasome-mediated degradation.
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Authors
Kemin Song, Shaowen Peng, Zheng Sun, Haitao Li, Rongya Yang,