| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763327 | Biochemical and Biophysical Research Communications | 2011 | 8 Pages |
Abstract
⺠LAB reduced the ROS production in HEK293T cells cultured under oxidative stress. High dose of glucose enhanced the expression of HO-1 mRNA and HO-1 protein in a time-dependent manner. ⺠LAB enhanced the expression of HO-1 mRNA and HO-1 protein in a dose-dependent manner treated with high dose of glucose. ⺠LAB plays an important role against glucose-induced intracellular oxidative damage. ⺠The enhanced expression of HO-1 mRNA and HO-1 protein caused by LAB is regulated via Nrf2 signal pathway.
Keywords
NF-κBMDAReative oxygen speciesGSTsHeme oxygenase-1AP-1DCFH-DAqRT-PCRCPKHO-1Nrf2CATDcf2′,7′-dichlorodihydrofluorescein2′,7′-dichlorodihydrofluorescein diacetateEpREGSH-PxO2−ROSHydrogen peroxideLABsuperoxide anionSODSuperoxide dismutaseantioxidant response elementelectrophile response elementnuclear factor kappa BMagnesium lithospermate BmalondialdehydeAREH2O2quantitative reverse transcription polymerase chain reactionpolymerase chain reactionPCRactivator protein 1Kelch-like ECH-associated protein 1Creatine phosphokinaseglutathione S-transferasesglutathione peroxidaseReactive oxygen species
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Authors
Jian Qu, Xian Ren, Rui-ying Hou, Xing-ping Dai, Ying-chun Zhao, Xiao-jing Xu, Wei Zhang, Gan Zhou, Hong-hao Zhou, Zhao-qian Liu,