Article ID Journal Published Year Pages File Type
10763357 Biochemical and Biophysical Research Communications 2011 5 Pages PDF
Abstract
► Tumor-surrounding adipocytes contribute to breast cancer progression. ► Breast tumor cells previously co-cultivated with mature adipocytes exhibit radioresistance. ► Increased in Chk1 phosphorylation is observed in irradiated co-cultivated tumor cells. ► IL-6 is over-expressed in tumor cells co-cultivated with adipocytes. ► IL-6 exposure confers increased Chk1 phosphorylation and radioresistance in tumor cells.
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