| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763386 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Primary proinsulin maturation disorder is inherent in Ins2+/Akita islets/β-cells. ⺠A consequence is the inefficient conversion of proinsulin to insulin. ⺠Post-translational defects occur as well in the involved PC1/3 and PC2 convertases. ⺠Proinsulin maturation chaos results in defects in the following conversion process. ⺠A link of the proinsulin maturation disorder and hyperproinsulinemia is suggested.
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Authors
Jie Wang, Kwame Osei,