Article ID Journal Published Year Pages File Type
10763388 Biochemical and Biophysical Research Communications 2011 6 Pages PDF
Abstract
► We characterized the pattern of gene expression and aberrations in DNA copy number of 6-MP- and 6-TG-resistant cells. ► Two transporters were downregulated in both cell lines confirming their role in the uptake of thiopurines by cells. ► DNTT gene was expressed by 6-TG- and 6-MP-resistant cells at levels higher than wild-type cells. ► Specific inhibitors of DNTT gene might be developed into a novel class of antitumor agents.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells
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