| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763443 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Imidazoline I1 receptor (IR1) is involved in suppression of sympathetic outflow. ⺠We determine cellular mechanism of IR1-induced sympatholytic effect in superior cervical ganglion neurons. ⺠Activation of IR1 in SCG neurons reduce ICa-N in rat and this inhibition lead to attenuation of repetitive AP firing in SCG neurons. ⺠These results suggest for the first time cellular mechanisms for pharmacological effects of IR1 activation in peripheral sympathetic nervous system.
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Authors
Young-Hwan Kim, Taick-Sang Nam, Duck-Sun Ahn, Seungsoo Chung,