Article ID Journal Published Year Pages File Type
10763493 Biochemical and Biophysical Research Communications 2011 4 Pages PDF
Abstract
► Linezolid, the first marketed oxazolidinone antibiotic is a MAO-A inhibitor. ► MAO-A enzyme regulates the catabolism of monoamine neurotransmitters in the brain. ► Depression is associated with functional deficiency of catecholamine neurotransmitters in synaptic cleft. ► Linezolid showed anti-depressant-like effect in rodent's behavioral model.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - An investigation using behavioral tests battery of depression
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