| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763505 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠ALCAPs are topoisomerase I enzyme inhibitors in vitro. ⺠DNA damage occurs subsequent to cytochrome C release after 6 h of treatment. ⺠ALCAP2, 7 and 8, induce apoptosis, result PARP cleavage and DNA damage response. ⺠ALCAPs generate ROS, activates H2AX and ATM phosphorylations in leukemia cell K562. ⺠Antioxidant l-NAC abrogates ROS mediated apoptosis, induced by ALCAPs.
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Authors
Nuray Bogurcu, Canan Sevimli-Gur, Besra Ozmen, Erdal Bedir, Kemal Sami Korkmaz,