| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763514 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠ZL11n is a novel nitric oxide-releasing derivative of farnesylthiosalicylic acid that induces significant apoptosis in human hepatoma cells but not normal hepatocytes. ⺠ZL11n induced apoptosis by the co-operation of mitochondrial apoptotic pathway activated by NO and MAPKs signaling pathway triggered by JNK or ERK. ⺠In vivo study also indicated ZL11n could significantly reduced tumor volumes and tumor weight in H22 murine solid tumor model.
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Authors
Lifang Yang, Yong Ling, Zhenzhen Zhang, Qian Zhao, Jianxin Tang, Hui Ji, Yihua Zhang,