| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763517 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Indoxyl sulfate (IS) inhibits nitric oxide (NO) release in endothelial cells. ⺠IS inhibits endothelial cell migration and tube formation in vitro. ⺠NO donor, SNAP, reverses the inhibitory effects of IS on endothelial cells. ⺠IS inhibits ERK MAP kinase activity in endothelial cells which is prevented by SNAP. ⺠IS activates myosin light chain in endothelial cells which is down-regulated by SNAP.
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Authors
Sourabh Kharait, Daniel J. Haddad, Matthew L. Springer,