Casuarinin suppresses TNF-α-induced ICAM-1 expression via blockade of NF-κB activation in HaCaT cells

► Casuarinin inhibited TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness in HaCaT cells. ► Casuarinin significantly inhibited TNF-α-induced activation of NF-κB and ERK/p38 MAPK. ► Casuarinin decreased TNF-α-induced pro-inflammatory mediators, such as IL-1β, IL-6, IL-8, and MCP-1.