| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763530 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Human genes were screened that were drastically changed by the complete adipogenic induction cocktail, but not by the individual components. ⺠The resultant 12 genes showed different kinetic profiles of expression levels during adipogenesis of human mesenchymal stem cells. ⺠These genes are potentially regulated cooperatively by at least two different signaling pathways. ⺠This study identified candidates of novel adipogenic regulators that mediate cross-talks of multiple adipogenic pathways.
Keywords
RGS2KCNK3SLCO2A1HSD11B1Gene screeningNOX4TGFCA2PPARγPI3KhMSCsDEXIBMX3-isobutyl-1-methylxanthineC/EBPMAPKNADPH oxidase 4Adipogenesistransforming growth factorDexamethasoneStarhuman mesenchymal stem cellhuman mesenchymal stem cellsphosphoinositide 3-kinaseCCAAT/enhancer-binding proteinmitogen-activated protein kinaseFunctional genomicscarbonic anhydrase IIPeroxisome proliferator-activated receptor gamma
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Authors
Tomoya Ito, So Tsuruta, Koki Tomita, Kunio Kikuchi, Takahide Yokoi, Yasunori Aizawa,