Article ID Journal Published Year Pages File Type
10763533 Biochemical and Biophysical Research Communications 2011 7 Pages PDF
Abstract
► Effect of lymphotoxin (LT) on major histocompatibility complex class I (MHC I) expression was examined in HPV-infected cervical cancer cells. ► E6 oncogene from HPV16, but not HPV18, suppressed MHC I expression. ► HPV16E6 upregulated the expression of LT and its receptor, LTβR. ► HPV16E6-mediated MHC I suppression occurs via the LT signaling pathway.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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Human papillomavirus 16E6 suppresses major histocompatibility complex class I by upregulating lymphotoxin expression in human cervical cancer cells
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