Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10763540 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Two isoforms of selenocysteine (Sec) tRNA[Ser]Sec differ by a single methyl group (Um34) and synthesize different subclasses of selenoproteins. ⺠The relationship between tRNA[Ser]Sec aminoacylation and Um34 synthesis was investigated. ⺠The data show that tRNA[Ser]Sec must be aminoacylated, most likely with Sec, for Um34 synthesis to occur. ⺠The data provide an explanation why selenium is essential for the function of Um34 methylase. ⺠The data provide further insights into the hierarchy of selenoprotein expression.
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Authors
Jin Young Kim, Bradley A. Carlson, Xue-Ming Xu, Yu Zeng, Shawn Chen, Vadim N. Gladyshev, Byeong Jae Lee, Dolph L. Hatfield,