| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763553 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠The tumor suppressor CHFR binds and regulates the spindle checkpoint protein MAD2. ⺠CHFR/MAD2 interaction is abolished by deletion of the cysteine-rich domain of CHFR. ⺠CHFRÎCys is unable to rescue the mislocalization of MAD2 in CHFRâ/â MEFs. ⺠CHFRÎCys expression does not rescue the mitotic defect seen in CHFRâ/â MEFs. ⺠MAD2/CDC20 interaction is reduced in CHFRâ/â MEFs expressing CHFRÎCys.
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Authors
Jennifer A. Keller, Elizabeth M. Petty,