Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10763556 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Alcohol-induced liver disease is associated with high morbidity and mortality. ⺠Although chronic alcohol exposure causes norepinephrine (NE) release leading to hepatic injury, the mechanism has not been fully elucidated. ⺠We induced chronic alcohol conditions in vivo and in vitro and examined the α2A-adrenoceptor mediated hepatic damage. ⺠Our results showed that chronic alcohol exposure elevates NE and upregulates Kupffer cell α2A-adrenoceptors to release TNF-α. ⺠Alcohol induced downregulation of MKP-1 leads to further release of TNF-α and hepatic injury.
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Authors
Michael A. Ajakaiye, Asha Jacob, Rongqian Wu, Mian Zhou, Youxin Ji, Weifeng Dong, Zhimin Wang, Xiaoling Qiang, Wayne W. Chaung, Jeffrey Nicastro, Gene F. Coppa, Ping Wang,