Article ID Journal Published Year Pages File Type
10763556 Biochemical and Biophysical Research Communications 2011 6 Pages PDF
Abstract
► Alcohol-induced liver disease is associated with high morbidity and mortality. ► Although chronic alcohol exposure causes norepinephrine (NE) release leading to hepatic injury, the mechanism has not been fully elucidated. ► We induced chronic alcohol conditions in vivo and in vitro and examined the α2A-adrenoceptor mediated hepatic damage. ► Our results showed that chronic alcohol exposure elevates NE and upregulates Kupffer cell α2A-adrenoceptors to release TNF-α. ► Alcohol induced downregulation of MKP-1 leads to further release of TNF-α and hepatic injury.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Authors
, , , , , , , , , , , ,