| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763563 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠LNA-modified oligonucleotides can pass through the plasma membrane of cultured cells even without using transfection machinery. ⺠LNA-modified oligonucleotides passed efficiently across the cell membrane, and lipid-coating facilitated translocation from the cytoplasm to the nucleus. ⺠LNA-oligonucleotide designed to target nuclear HBV DNA efficiently suppresses HBV replication and transcription in cultured hepatic cells.
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Authors
Zhen Sun, Wenqing Xiang, Yajuan Guo, Zhi Chen, Wei Liu, Daru Lu,