Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10763563 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠LNA-modified oligonucleotides can pass through the plasma membrane of cultured cells even without using transfection machinery. ⺠LNA-modified oligonucleotides passed efficiently across the cell membrane, and lipid-coating facilitated translocation from the cytoplasm to the nucleus. ⺠LNA-oligonucleotide designed to target nuclear HBV DNA efficiently suppresses HBV replication and transcription in cultured hepatic cells.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Zhen Sun, Wenqing Xiang, Yajuan Guo, Zhi Chen, Wei Liu, Daru Lu,