| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763580 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠PHBP (FSAP) is a serine protease circulating as a single-chain proenzyme (pro-PHBP). ⺠Extracellular histones, released under hyperinflammation, mediate toxic effects. ⺠We find that histones potently promote the activation pro-PHBP via formation of autoactivation complex. ⺠Pro-PHBP activation in plasma affords bradykinin and PHBP-α2-antiplasmin complex. ⺠Pro-PHBP activation is observed in a sepsis model, suggesting pathophysiological role.
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Authors
Shingo Yamamichi, Yukari Fujiwara, Tadashi Kikuchi, Miki Nishitani, Yasuhiko Matsushita, Keiji Hasumi,