| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763614 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠Lysophosphatidic acid (LPA) levels and its receptors LPAR1/3 transcripts were elevated during the development of radiation-induced lung fibrosis. ⺠Lung fibrosis was obviously alleviated in mice treated with the dual LPAR1/3 antagonist, VPC12249. ⺠VPC12249 administration effectively inhibited radiation-induced fibroblast accumulation in vivo, and suppressed LPA-induced fibroblast proliferation in vitro. ⺠LPA-LPAR1/3 signaling regulated TGFβ1 and CTGF expressions in radiation-challenged lungs, but only influenced CTGF expression in cultured fibroblasts. ⺠LPA-LPAR1/3 signaling induced fibroblast proliferation through a CTGF-dependent pathway, rather than through TGFβ1 activation.
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Authors
Lu Gan, Jian-Xin Xue, Xin Li, De-Song Liu, Yan Ge, Pei-Yan Ni, Lin Deng, You Lu, Wei Jiang,