Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice

Article ID	Journal	Published Year	Pages	File Type
10763618	Biochemical and Biophysical Research Communications	2011	6 Pages	PDF

Abstract

âº Insulin resistance does not accelerate amyloid deposition or memory loss in AD mice. âº The insulin receptor mutation reduced oxidative damage in AD mice. âº Insulin resistance and hyperinsulinemia is not always involved in AD progression.

Keywords

amyloid β Alzheimer’s disease Insulin signaling Senile plaque Insulin resistance Hyperinsulinemia

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice

Authors

Kazuma Murakami, Shin-ichi Yokoyama, Nakaba Murata, Yusuke Ozawa, Kazuhiro Irie, Takuji Shirasawa, Takahiko Shimizu,