| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763655 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠CaMKIIδA is upregulated in both neonatal and adult cardiac hypertrophy models. ⺠Silencing CaMKIIδA gene blunts cell enlargement and hypertrophic cardiac gene reactivation. ⺠Activation of the HDAC4-MEF2 signaling pathway is inhibited by CaMKIIδA silencing. ⺠Our results provide new evidence for selective interference of cardiac hypertrophy and heart failure.
Keywords
ANFAtrial natriuretic factor (ANF)NRVMARVMβMHCPKDMEF2CaMKIIqPCRNFATHDACGAPDHNeonatal rat ventricular myocytessiRNAISOisoproterenolβ-myosin heavy chainmyocyte enhancer factor-2atrial natriuretic factorCANadult rat ventricular myocyteshistone deacetylaseHistone deacetylase (HDAC)Cardiac hypertrophyquantitative real-time polymerase chain reactionprotein kinase DCalcineuringlyceraldehyde-3-phosphate dehydrogenase
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Authors
Changlin Li, Xiangyu Cai, Haili Sun, Ting Bai, Xilong Zheng, Xing Wang Zhou, Xiongwen Chen, Donald L. Gill, Jing Li, Xiang D. Tang,