| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763670 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Fbxo25 expression is higher in a fetal heart than that of an adult and is nuclei-specific in mouse and human cardiomyocytes. ⺠It increases along with those of cardiac-specific genes during differentiation from ESCs. ⺠It facilitates protein degradation of Nkx2-5, Isl1, Hand1, and Mef2C. ⺠These degradations are promoted by ubiquitination depending on Fbxo25. ⺠Thus, Fbxo25-mediated UPS has a pivotal impact on cardiac development.
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Authors
Jae-Woo Jang, Won-Young Lee, Jae-Ho Lee, Sung-Hwan Moon, Chang-Hoon Kim, Hyung-Min Chung,