| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763673 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠In skeletal muscle overexpression of IGF-1Ea mobilizes bone marrow stem cell favouring tissue repair and integrity. ⺠We observed that in cardiac muscle IGF-1Ea induces VEGF and MCP2 expression. ⺠Increased number of c-Kit/Sca1 positive cells in the bone marrow correlates with the cytokine profile. ⺠Moreover, cardiac side population is primed to form endothelial-like tubular structure by IGF-1Ea. ⺠The above signaling correlates with recapillarization of the cardiac tissue in the area bordering the infarct.
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Authors
Maria Paola Santini, Jonas Lexow, Giovanna Borsellino, Esfir Slonimski, Elham Zarrinpashneh, Tommaso Poggioli, Nadia Rosenthal,