Article ID Journal Published Year Pages File Type
10763678 Biochemical and Biophysical Research Communications 2011 6 Pages PDF
Abstract
► The Streptococcus suis NeuA is characterized for the first time. ► The CMP-Neu5Ac synthetase domain alone was inactive, while esterase domain alone was active. ► S.suis NeuA strictly de-O-acetylated CMP-O-acetyl-Neu5Ac, whereas Escherichia coli NeuA preferentially de-O-acetylated CMP-O-acetyl-Neu5Ac. ► The NeuA O-acetylesterase is essential for synthesis of capsular Neu5Ac in E. coli.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
NeuA O-acetylesterase activity is specific for CMP-activated O-acetyl sialic acid in Streptococcus suis serotype 2
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