Article ID Journal Published Year Pages File Type
10763688 Biochemical and Biophysical Research Communications 2011 7 Pages PDF
Abstract
► The UTRs of tumor suppressor gene FUS1/TUSC2 mRNA play an important role in regulation of FUS1 expression in human bronchial epithelia and lung cancer cells. ► Two uORFs in the 5′UTR inhibit FUS1 translation initiation by interfering with the scanning of the ribosome initiation complexes. ► Several RNA sequence elements/motifs in 3′UTR significantly downregulate FUS1 protein expression. ► The 3′UTR regulates FUS1 expression differentially in normal lung and tumor cells.
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