Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10763688 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠The UTRs of tumor suppressor gene FUS1/TUSC2 mRNA play an important role in regulation of FUS1 expression in human bronchial epithelia and lung cancer cells. ⺠Two uORFs in the 5â²UTR inhibit FUS1 translation initiation by interfering with the scanning of the ribosome initiation complexes. ⺠Several RNA sequence elements/motifs in 3â²UTR significantly downregulate FUS1 protein expression. ⺠The 3â²UTR regulates FUS1 expression differentially in normal lung and tumor cells.
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Authors
Jing Lin, Kai Xu, Jayachandran Gitanjali, Jack A. Roth, Lin Ji,