Article ID Journal Published Year Pages File Type
10763697 Biochemical and Biophysical Research Communications 2011 6 Pages PDF
Abstract
► Exposure of human brain microvascular endothelial cells (HBMEC) monolayer to PFOS increased the paracellular permeability. ► PFOS induced disassembly of tight junction (TJ) in HBMEC monolayer. ► Activation of PI3K/Akt signaling in HBMEC is required for PFOS-triggered brain endothelial TJ disruption.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Perfluorooctane sulfonate triggers tight junction “opening” in brain endothelial cells via phosphatidylinositol 3-kinase
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