| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763744 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Organ transplant recipients are highly susceptible to early skin cancer development. ⺠CsA-mediated TGFB1-dependent TAK1/TAB1 signaling augments invasive tumor growth. ⺠CsA enhances accumulation of upstream kinases, ZMP, AMPK and IRAK to activate TAK1. ⺠TAK1 mediates enhanced proliferation and reduced apoptosis via CsA-dependent NFκB.
Keywords
AMPKOTRsTAB1SCCMPPIKKβUVBNMSCTAK1BCCIκBAMP-activated protein kinaseIκB kinase βNFκBultraviolet BCSAnonmelanoma skin cancerNon-melanoma skin cancerImmune suppressionCyclosporine AIRAKVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)nuclear factor κBnuclear factor kappa Binhibitory κBBasal cell carcinomaSquamous cell carcinomainterleukin-1 receptor associated kinaseOrgan transplant recipients
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Authors
Jianmin Xu, Stephanie B. Walsh, Zoe M. Verney, Levy Kopelovich, Craig A. Elmets, Mohammad Athar,