| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763749 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Growth hormone (hGH) suppresses FAT/CD36 mRNA levels in insulin secreting β-cells and rat islets. ⺠Inhibition of FAT/CD36 using siRNAs protects against palmitate-induced apoptosis. ⺠Accordingly, growth hormone decreases fatty acid uptake and apoptosis and improves glucose-induced insulin secretion. ⺠Growth hormone can protect β-cells against fatty acid-induced damages via down-regulation of FAT/CD36.
Keywords
LactogenFABP2FATP4GFPFATP1GSISFATPPRLRPRLFABPGPR40FAT/CD36hGHPancreatic β-cellSTATFatty acidfatty acid synthasefatty acid translocaseGlucose-stimulated insulin secretionApoptosisconstitutively activedominant negativeFasnGrowth hormoneHuman growth hormoneFatty acid binding proteinFatty acid transport proteingreen fluorescent proteinProlactinFatprolactin receptor
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Authors
Louise T. Dalgaard, Peter Thams, Louise W. Gaarn, Janne Jensen, Ying C. Lee, Jens H. Nielsen,