Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality

► Deletion of Dicer in vascular smooth muscle cells(VSMCs) leads to embryonic mortality. ► Loss of Dicer in VSMCs leads to developmental delay. ► Loss of Dicer in VSMCs leads to hemorrhage in various organs including brain, skin and liver. ► Loss of Dicer in VSMCs leads to vascular wall remodeling. ► Loss of Dicer in VSMCs dysregulates the expression of miRNA and VSMC marker genes.