| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763785 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠We report biochemical and functional data for T. cruzi PTP1. ⺠We were able to demonstrate inhibition of TcPTP1 by the PTP1b inhibitor BZ3. ⺠BZ3 accelerates the differentiation of epimastigotes into metacyclic forms. ⺠BZ3 was able to inhibit by 50% the infectivity of T. cruzi trypomastigotes. ⺠TcPTP1 is of importance for differentiation and invasivity of T. cruzi.
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Authors
Gloria Gallo, Thiago Cesar Prata Ramos, Fernanda Tavares, Antonio A. Rocha, Emerson Machi, Sergio Schenkman, Diana Bahia, João Bosco Pesquero, Martin Würtele,