| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763787 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠We investigated GHR determinants of sequential α- and γ-secretase cleavage. ⺠γ-Secretase cleavage occurs at a transmembrane domain ε-site. ⺠Deletion of two proximal transmembrane residues prevents α-/γ-secretase proteolysis. ⺠Deletion of four ε-site residues prevents surface expression and proteolysis. ⺠Point mutations in and around the ε-site did not affect α-/γ-secretase cleavage.
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Authors
Xiangdong Wang, Jon W. Cowan, Mary Gerhart, Blake R. Zelickson, Jing Jiang, Kai He, Michael S. Wolfe, Roy A. Black, Stuart J. Frank,