Article ID Journal Published Year Pages File Type
10763799 Biochemical and Biophysical Research Communications 2011 6 Pages PDF
Abstract
► We screened and identified Tyrphostin A9, a receptor tyrosine kinase inhibitor as a strong mitochondria fission inducer. ► Tyrphostin A9 treatment promotes mitochondria dysfunction and contributes to cytotoxicity in cancer cells. ► Tyrphostin A9 induces apoptotic cell death through a Drp1-mediated pathway. ► Our studies suggest that Tyrphostin A9 induces mitochondria fragmentation and apoptotic cell death via Drp1 dependently.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation
Authors
, , , , , , , ,