Article ID Journal Published Year Pages File Type
10763823 Biochemical and Biophysical Research Communications 2011 7 Pages PDF
Abstract
► FSP1+ fibroblasts participate in elastic cartilage and fibrocartilage production. ► Loss of Smad4 in fibroblasts results in a short ear phenotype. ► Chondrocyte maturation is conducted via Smad4 signaling. ► BMP-5 induces differentiation of ear chondrocytes.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Deletion of Smad4 in fibroblasts leads to defective chondrocyte maturation and cartilage production in a TGFβ type II receptor independent manner
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