| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763832 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠All N-BPs induced IPP/ApppI formation in cells after pulse and continuous treatment. ⺠A significant relationship between Kisom values and IPP/ApppI formation was observed. ⺠NE21650, an analog of RIS, inhibit IPP isomerase enzyme. ⺠Kisom calculations are useful for evaluation the potency of the novel FPPS inhibitors. ⺠IPP/ApppI analysis is a sensitive method to monitor the action of FPPS inhibitors.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Johanna Räikkönen, Markku Taskinen, James E. Dunford, Hannu Mönkkönen, Seppo Auriola, Jukka Mönkkönen,