| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763839 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠Involvement of MMPs and HER (ErbB) family pathway in cancer cell invasion and tumor progression has been well established. ⺠Our results suggest that the expression of ligands of EGFR, and MMP1 by SK-BR3 breast cancer cells can collectively promote progression potential. ⺠Furthermore, targeting HER (ErbB) family pathway by TKIs suppressed EGF ligands-induced MMP1 expression. ⺠Targeting of MMP1 by inhibition of EGFR signaling has possibility as a therapeutic strategy.
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Authors
Sarah Park, Hae Hyun Jung, Yeon Hee Park, Jin Seok Ahn, Young-Hyuck Im,