| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763846 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠Zinc deficiency impairs cell-mediated immunity in humans. ⺠We find zinc increases the expression of IL-2, IFN-γ, IL-12Rβ2, and T-bet, essential for Th1-cell differentiation in Th0 cells. ⺠Zinc-specific chelator, TPEN, decreases the mRNA expression of IFN-γ and T-bet in Con-A-stimulated cells. ⺠High level of zinc increases intracellular free zinc in Con-A-stimulated cells. ⺠We hypothesize that free zinc is a molecular signal involved in expression of cytokines and transcription factors.
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Authors
Bin Bao, Ananda S. Prasad, Frances W.J. Beck, Ginny W. Bao, Tapinder Singh, Shadan Ali, Fazlul H. Sarkar,